Health & Medical Neurological Conditions

CSF Leakage in the Setting of Pituitary Adenomas

´╗┐CSF Leakage in the Setting of Pituitary Adenomas


Nonsurgical development of CSF rhinorrhea may occur in the setting of pituitary adenomas, especially following initiation of medical therapy. The most common situation occurs in the setting of invasive prolactinomas that respond favorably to dopamine agonist therapy. Additional cases of spontaneous CSF leakage have been reported as the presenting symptom of a pituitary adenoma and are likely to be related to decreased tumor volume due to intrinsic infarction or hemorrhage, ongoing tumor invasion, and/or increases in intracranial pressure. In almost all cases, surgical treatment is warranted to repair the CSF leak and achieve maximal tumor resection.

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