Health & Medical First Aid & Hospitals & Surgery

Apoptosis in Skin Wound Healing

´╗┐Apoptosis in Skin Wound Healing
Apoptosis, a basic physiological process in which unwanted cells are removed, plays an important role in the wound healing process. In normal skin wound healing, apoptosis is responsible for the removal of inflammatory cells and the evolution of granulation tissue into scar. Dysregulation in apoptosis can lead to abnormal wound healing, such as hypertrophic scar and keloid formation. This review first provides an overview of the basic molecular aspects of apoptosis and wound healing, followed by the elucidation of apoptosis in the normal and abnormal wound healing processes. As research in this area ensues, knowledge of apoptosis may be helpful in designing novel therapies for wound healing.

Apoptosis is a highly conserved physiological cell death process that removes unwanted cells. Since 1972 when Kerr, et al., introduced the term apoptosis to distinguish from necrosis, there has been tremendous interest in programmed cell death as a critical component in maintaining homeostasis and growth in tissues. Failure of apoptosis can lead to a variety of cancers, viral infections, and autoimmune diseases. Since the past three decades when the mystery of this cellular phenomenon began to unravel, scientists have discovered its valuable applications in clinical research and biotechnology. One area of particular importance is the wound healing process in which apoptosis is responsible for the removal of inflammatory cells and granulation tissue. While extensive literature in apoptosis has been published in many fields, very few have focused on the role of apoptosis in the skin wound healing process. This review describes the basic cellular and biochemical aspects of apoptosis and the occurrence of apoptosis during the skin wound healing and regeneration process.

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